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The 2026 "12-Hour" Recommendation In 2026, many US clinicians have moved away from recommending intense 16:8 or 20:4 windows for semaglutide users
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When dietary carbohydrate supply is restricted, glycogen stores in the liver are depleted in just 24 h, and those in the muscles are consumed over the next few days, with a consequent loss of water (bound to glycogen) [109,111,112]